Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg tablet is a penicillin G derivative and an antibacterial drug that is used to treat certain bacterial infections. It is also used together with other medicines to treat stomach ulcers caused by a type of bacteria known as Helicobacter pylori.
Amoxycillin may be used to treat other conditions as decided by your doctor.
Drug = Amoxycillin
Strength = 500/125 mg
Manufacturer = GSK Pharma
Quantity per sleeve = 10 Tabs
How To Take Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg
Amoxycillin may be taken with or without food. It is best to take it with food to minimise stomach discomfort.
Amoxycillin is available as an oral tablet, capsule or oral suspension.
If you are taking the delayed-release, prolonged-release, sustained-release or extended-release type of tablet (may be labelled “ER”), swallow it whole. Do not divide, chew or crush the tablet. It is best to take it within 1 hour of the meal.
Amoxycillin must be taken at regular intervals for it to be effective. Continue to take this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Amoxycillin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg
Susceptible infections: 250-500 mg 8 hourly or 500-875 mg 12 hourly.
Uncomplicated gonorrhea: 3 g as single dose with probenecid.
Dental abscesses: 3 g, repeat once after 8 hours.
Uncomplicated acute UTI: 3 g, repeat once after 10-12 hours.
Prophylaxis of endocarditis: 2 g as a single dose, 1 hour before surgical procedure.
Severe or recurrent respiratory tract infections: 3 g twice a day.
H. pylori infection: 750 mg or 1,000 mg twice a day or 500 mg three times a day, with either metronidazole or clarithromycin and a proton pump inhibitor.
Tonsillitis; Pharyngitis: As extended-release tab: 775 mg/day for 10 days.
Missed Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
Overdose
Signs of overdose may include the following:
- Nausea
- Vomiting
- Diarrhea
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Amoxycillin:
- Hypersensitivity to amoxicillin and other penicillins
Side Effects of Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg
Amoxycillin may have the following side effects:
- Nausea
- Vomiting
- Diarrhea
- Black hairy tongue
- Serum sickness-like reactions
- Erythematous maculopapular rashes
- Erythema multiforme
- Stevens-Johnson syndrome
- Exfoliative dermatitis
- Toxic epidermal necrolysis
- Acute generalised exanthematous pustulosis
- Hypersensitivity vasculitis
- Urticaria
- Increased AST and ALT
- Cholestatic jaundice
- Hepatic cholestasis
- Acute cytolytic hepatitis
- Crystalluria
- Anemia
- Thrombocytopenia
- Thrombocytopenic purpura
- Eosinophilia
- Leucopenia
- Agranulocytosis
- Reversible hyperactivity
- Agitation
- Anxiety
- Insomnia
- Confusion
- Convulsions
- Behavioural changes
- Dizziness
- Tooth discoloration
Potentially Fatal:
- Anaphylaxis
- Clostridium difficile-associated diarrhea (CDAD)
- Pseudomembranous colitis
Warnings of Amoxycillin (Augmentin 625 – Augmentin 625 Duo) 500/125 mg
Alert your doctor if you have a history of allergic reactions to penicillin antibiotics and cephalosporin antibiotics.
Inform your doctor and pharmacist if you are taking any of these medicines:
- Probenecid
- Allopurinol
- Methotrexate
- Warfarin
- Chloramphenicol
- Erythromycin
- Tetracycline
- Birth-control pills.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Amoxycillin.
How Does It Work?
Amoxycillin works by inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to 1 or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.
Uses
Amoxycillin is used to treat the following conditions:
- Susceptible infections
- Dental abscesses
- Uncomplicated gonorrhea
- Uncomplicated acute UTI
- Prophylaxis of endocarditis
- H. pylori infection
- Tonsillitis
- Pharyngitis
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with history of beta-lactam allergy
- Infectious mononucleosis
- Renal impairment
- Pregnancy
- Lactation
- Avoid alcohol
Storage Conditions
- Store between 20-25°C.
- Store in a cool, dry place away from the reach of children. Protect from light and moisture.
- Do not use Amoxycillin that is expired or out of expiry date.
